Varicella infection-induced cases, once the most common single Acute cerebellar ataxia, acute cerebellitis, and opsoclonus-myoclonus syndrome. J Child Department With Acute Ataxia in the Post-Varicella Vaccine Era. Acute post-infectious cerebellar ataxia is the most common cause of About 20 % of cases have been linked to varicella (chicken pox), but it. Post-viral cerebellar ataxia also known as acute cerebellitis and acute cerebellar ataxia (ACA) Viral infections that may cause it include the following: chickenpox, Coxsackie disease (viral infection also called hand-foot-and-mouth disease).

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Infections may need to be treated with antibiotics.

We present a series of three cases with neurological presentations following chicken pox infection. There were no thickened nerves and no vertebral abnormality clinically. Table 2 shows major investigation and diagnosis.

Acute cerebellitis in children: an eleven year retrospective multicentric study in Italy

Other imaging tests like EEG electroencephalographs and MRI magnetic resonance imaging can also be performed to eliminate possible diagnoses of other severe diseases, such as neuroblastomadrug intoxication, acute labyrinthitisand metabolic diseases. On general examination, there were hyperpigmented spots all over the body, suggestive of healed chicken pox recently.

Varicella-zoster virus infections of the central nervous system — Prognosis, diagnostics and treatment. Follow-up was performed according to the local experience of each center.

Severity was divided in three classes: On the 10th day, she suddenly realized that she could not move all her four limbs while she was lying down. In the literature, the median age of children affected by AC was 4. AC, the most common neurological complication of varicella, occurs about once in varicella cases among children.


Anyway, the result of these tests did not change the treatment. This is in line with the literature, in which the median time between the onset of exanthema and hospital admission was 7 days. The hospitalization of our patients was longer than those reported in the literature 6.

Out of 67 children, Rack et al. The mean time of onset for cerebellar cerebelutis was 7. Khu KJ, Bernstein M. Instead in a previous report in which children affected by AC median age 4. The examination of the nervous system revealed flaccid paraplegia of both lower limbs.

Radiculopathy is commoner when the virus reactivates, but it can also occur in the primary cerebe,itis pox disease.

CSF electrophoresis was not done. Acute cerebellar ataxia is the most common neurological complication of varicella infection, occurring in 1: Clinical and pathologic correlates. The newer PCR technique is more sensitive.

Acute cerebellitis AC and acute cerebellar ataxia ACA are the principal causes vadicela acute cerebellar dysfunction in childhood. Serum paired samples at an interval of 10 days showed rising titer of anti-VZV antibody 1: Some authors reported that acyclovir is indicated because of disease severity, while others did not recommend it, based on the strength of evidence regarding autoimmune pathogenesis [ 22 – 252829 ].

Post chicken pox neurological sequelae: Three distinct presentations

Acute cerebellitis with near-fatal cerebellar swelling and benign outcome under conservative treatment with high dose steroids. Grahn A, Studahl M.

Contributor Information Laura Lancella, Email: J Microbiol Immunol Infect. A common measure of varicella complications is derived from the hospitalization of patients. From each article analyzed we extrapolated the total number of varicella cases, the number of cases with neurological complications and the number of cases with cerebellar involvement.


May result from neurological disease, metabolic disease or other systemic disorders. All patients presented with cerebellar symptoms either on the crusted phase or in any case not before day 5 of the disease. Viral infections that may cause it include the following: However those children who have unexplained ataxia require admission for investigation.

In immunocompromised host, the virus can invade deeper tissues and the virus has been isolated from brain tissue or ventricles by polymerase chain reaction PCR.

Acute cerebellitis in children: an eleven year retrospective multicentric study in Italy

All authors read and approved the final manuscript. Neurological complications were identified in 92 out of patients Six children, 5 boys and 1 girl, aged 2. In a few cases, irritability vsricela. At admission, ataxia was the most frequent symptom, with wide-based gait In four patients neurological symptoms developed in the first two days. Magn Reson Med Sci.

Median follow-up time was 1 year. Neurological complications following primary chicken pox infection are extremely rare 0. Jerks were increased in both the lower limbs and plantar was extensor bilaterally.

Sensory examination showed no involvement with intact bladder and bowel sensations.

Support Center Support Center. Postvaricella cerebellar ataxia in children in Costa Rica. ATM is a condition of sudden weakness of lower extremities with sensory involvement caused due to inflammation of the spinal cerebelotis. Diffuse high signal intensity of both cerebellar hemispheres with prevalence on the right lobe black arrows.