Printed in China Library of Congress Cataloging-in-Publication Data Klabunde, Richard E. Cardiovascular physiology concepts / Richard E. Klabunde. Now in its second edition, this highly accessible monograph lays a foundation for understanding of the underlying concepts of normal. This uniquely readable, compact, and concise monograph lays a foundation of knowledge of the underlying concepts of normal cardiovascular function.

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For example, several regulate the movement of sodium through the different types of potassium channels exist channel Fig. We can derive the net electro- from 4 to 10 mM, the chemical gradient for diffu- chemical force acting on sodium from these sion out of the cell would be reduced; therefore, two component forces by subtracting the Em the membrane potential required to physlology minus ENa: Students may begin a path of questioning with, for example, a disease condition and then pursue background information through a series of links.

Handbook of Physiology, vol. Be the first to ask a question about Cardiovascular Physiology Concepts. cardioavscular

The cAMP acts as a second messenger to activate protein Enhanced calcium release by the sarcoplasmic kinase A cAMP-dependent protein kinase, reticulum also can increase inotropy Fig. Fuchs F, Smith SH. Although ventricular vol- reduced filling phase is the period during dias- ume does not change during isovolumetric tole when passive ventricular filling is nearing relaxation, atrial volumes and pressures con- completion.

The formation of diacylglycerol from PIP2 A third important mechanism for regulat- activates protein kinase C, which can modu- ing vascular smooth muscle contraction is the late vascular smooth muscle contraction as NO—cGMP system. Enhanced sequestering of calcium by intracellular calcium concentrations.

Welcome to Cardiovascular Physiology Concepts

Chemical interactions between the nected myocytes. The heart and vasculature ensure blood and alveolar gases. Kris added it Mar 11, The muscle shortens to the same minimal length when preload is increased. IP3 then directly stimulates the relaxes vascular smooth muscle through the sarcoplasmic reticulum to release calcium. Nor- Ventricular compliance is determined by cardiovascuoar, compliance curves are plotted with vol- the physical properties of the tissues mak- ume on the Y-axis and pressure on the X-axis, ing up the ventricular wall and the state of so that the compliance is the conceptts of the ventricular relaxation.


Conformational changes in the larized cells. In the latter case, lead I shows no net a wave of repolarization moving away from deflection because the wave of depolarization the left arm is seen as a positive deflection. Therefore, the textbook is particularly well-suited for first and second year medical students, as well as students in allied health sciences and health profession training programs e.

If increase in afterload e. Chapters contain problems and clinical cases that reinforce physiologic principles. Vagal stimulation has the opposite effects, and it hyperpolarizes the cell.

As the pressure pulse moves away from linear increase occurs in arterial pressure the heart, the systolic pressure rises, and the assuming that resistance and venous pressure diastolic pressure falls.

Cardiovascular Physiology Concepts

By itself, and myosin filaments slide past each other, this calcium influx does not significantly thereby shortening the sarcomere length this increase intracellular calcium concentrations is referred to as the sliding filament theory except in local regions just inside the sarco- of muscle contraction Fig.

Blood flow through an a given stroke volume. It connects the myosin filament to The cardiac myocyte is composed of bun- the Z-lines, which helps to keep the thick fila- dles of myofibrils that contain myofilaments ment centered within the sarcomere. One major difference is the for sodium to pass through the channel, effec- duration of the action potentials.


Furthermore, the caridovascular of mechanical node, whereas the left vagus nerve inner- events in the right side of the heart is very vates the AV node; however, significant over- similar to that of the left side.

Cardiovascular Physiology Concepts

The materials contained in this web site focus on physiological concepts that serve as the basis of cardiovascular disease. Calcium binding network called the sarcoplasmic reticulum to TN-C produces a conformation change in the that surrounds the myofilaments.

The valves from bulging back and leaking blood free wall of the right ventricle wraps around into the atria i. Because vessel length have only a minimal effect on changes in radius and diameter are directly resistance.

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Cardiovascular Physiology Concepts – Richard Klabunde – Google Books

The mechanism by which carfiovascular available to be taken up by the sarcoplasmic changes in length increase calcium affinity by reticulum and subsequently released.

This leads to calcium accumulation in The physiologic significance of this mecha- the cell; however, inotropy is not increased, in nism, however, is uncertain. These low-resistance intercellular con- by the tissue surrounding the blood vessel.

To keep items from the previous region in your cart, click cancel. The circulation trans- with blood vessels. The systemic circulation is com- and for exchange of heat, which is a major by- prised of all the blood vessels within and out- product of cellular metabolism that must be physiologh of organs excluding the lungs.

Blood then flows from the left atrium into the left ventricle.